Contents1 Global Burden of Breast Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Jacques Ferlay, Clarisse He´ ry, Philippe Autier,and Rengaswamy Sankaranarayanan
2 Breast Cancer Biology and Clinical Characteristics . . . . . . . . . . . . . . 21
Amanda I. Phipps and Christopher I. Li
3 In situ Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Brian L. Sprague and Amy Trentham-Dietz
4 Endogenous Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Amanda I. Phipps and Christopher I. Li
5 Exogenous Hormones. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89
Christopher I. Li and Elisabeth F. Beaber
6 Reproductive Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Mats Lambe
7 Physical Activity and Anthropometric Factors . . . . . . . . . . . . . . . . . . 137
Katherine D. Henderson, Jennifer Prescott,and Leslie Bernstein
8 Diet and Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Martin Lajous and Shumin M. Zhang
9 Environmental and Occupational Exposures . . . . . . . . . . . . . . . . . . . 183
Amanda I. Phipps, Dana Mirick, Christopher I. Li,and Scott Davis
10 Shift Work and Circadian Disruption. . . . . . . . . . . . . . . . . . . . . . . . . 223
Scott Davis and Dana K. Mirick
11 Non-Hormonal Medications and Chronic Diseases . . . . . . . . . . . . . . 243
Patricia F. Coogan
12 Male Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Ian S. Fentiman
13 Inherited Predisposition: Familial Aggregation and HighRisk Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Kathleen E. Malone and Kerryn W. Reding
14 Common Genetic Susceptibility Loci . . . . . . . . . . . . . . . . . . . . . . . . . 301
Mikkel Z. Oestergaard and Paul Pharoah
15 Mammographic Density as a Potential Surrogate Markerfor Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Norman F. Boyd, Lisa J. Martin, and Salomon Minkin
16 Breast Cancer Screening . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343
Karla Kerlikowske
17 Principles of Breast Cancer Therapy . . . . . . . . . . . . . . . . . . . . . . . . . 371
Allison W. Kurian and Robert W. Carlson
18 Breast Cancer Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
Graham A. Colditz and Courtney Beers
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 403
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